The Glomerular Filtration Barrier: Components and Crosstalk
نویسندگان
چکیده
منابع مشابه
The Glomerular Filtration Barrier: Components and Crosstalk
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents-the glomerular endothelial cell, the basement membrane and visceral epithelial...
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BACKGROUND The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on t...
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ژورنال
عنوان ژورنال: International Journal of Nephrology
سال: 2012
ISSN: 2090-214X,2090-2158
DOI: 10.1155/2012/749010